Medscape Education, encoded search term (Immunofixation) and Immunofixation, Fast Five Quiz: Multiple Myeloma Management, Emerging Interventions for Relapsed/Refractory Multiple Myeloma, Fast Five Quiz: Key Aspects of Multiple Myeloma, Highlights in Multiple Myeloma From ASH 2022, Use of Clinical Decision Support to Improve the Laboratory Evaluation of Monoclonal Gammopathies, FDA Calls for Withdrawal of Multiple Myeloma Drug Pepaxto. It causes periods of worsening symptoms and periods of remission. Oligoclonal bands in the CSF may also be seen in other illnesses such as: Systemic lupus erythematosus Human immunodeficiency virus (HIV) infection Stroke Normal Results Normally, one or no bands should be found in the CSF. Author Lone Frank talks about Dr. Robert Heath, who was hailed a pioneer and criticized as an exploiter during his career. Portions 2023 Mayo Foundation for Medical Education and Research. Oligoclonal bands are visible as an increased concentration of restricted bands of IgG after isoelectric focusing and immunofixation of IgG. What conditions show oligoclonal bands in serum? Clin Chem Lab Med. Red top tube for the collection of serum used. 1993 Jan;56(1):32-5. doi: 10.1136/jnnp.56.1.32. How the Test is Performed A sample of CSF is needed. In: Burtis CA, Bruns DE, eds. 2018 Feb;17(2):162-173, 4. IgA or IgM bands are less common. The symptoms of multiple sclerosis are unpredictable, varying from person to person and fluctuating over time. The results can help diagnose conditions of the central nervous. PMC Morris C, Drake M, Apperley J, et al. The following steps take place during a lumber puncture: You can expect to rest for an hour or two after your test. All rights reserved. The results of an EEG can be used to rule out or confirm. The procedure can vary depending on the doctors practices and the persons health status. Get a step-by-step look, CSF cell count and differential are measured during cerebrospinal fluid analysis. To determine the diagnostic significance of serum OCBs 146 patients with serum OCBs were identified among 1874 patients with suspected neurological disorders (7.6%). In a cohort of 1307 patients analyzed in 2018, where 159 had demyelinating disease, the Mayo Clinic oligoclonal banding test had a clinical sensitivity of 74% and clinical specificity of 89%, with a ROC AUC of 0.813 when 2 or more unique cerebrospinal fluid bands are used as a cutoff for positive. A. Typically, Botox is used to reduce the appearance of facial wrinkles. Unconcentrated CSF and diluted serum are electrophoresed by isoelectric focusing. The https:// ensures that you are connecting to the Am J Clin Pathol. Permission is granted in perpetuity, without payment of license fees or royalties, to use, copy, or distribute the LOINC codes for any commercial or non-commercial purpose, subject to the terms under the license agreement found at https://loinc.org/license/. What are Oligoclonal bands in CSF? These technical issues can lead to difficulties in distinguishing between negative results (type 1 pattern = absence of OCBs in serum and CSF and type 4 pattern = presence of identical OCBs in both serum and CSF) and results indicating intrathecal IgG synthesis (pattern 2 = presence of OCBs in CSF and type 3 = presence of OCBs in CSF and additional identical OCBs in both serum and CSF). However, they should let the doctor know about any medications they are taking, including blood thinners, and any medical history that relates to their spine. -, Neurology. 2010. A study from 2016 noted that more than 95% of all people living with MS have elevated levels of OCBs. 2010. Before This is particularly true if they dont find similar bands in your blood. Learn more. Background Meningoencephalitis of unknown origin (MUO) is an inflammatory disease of the canine central nervous system (CNS) that shares several features with multiple sclerosis (MS) in humans. 19952023 Mayo Foundation for Medical Education and Research. Make certain to include both prescription and over-the-counter medicines. government site. Multiple sclerosis is a disease that can cause permanent damage to your bodys nerves and the communication mechanisms between your brain and body. 8600 Rockville Pike Federal government websites often end in .gov or .mil. Lahuerta JJ, Jimenez-Ubieto A, Paiva B, et al. All Rights Reserved. Immunofixation consists of an electrophoresis phase and a fixation phase. Correale, J., & de los Milagros Bassani Molinas, M. (2002). Please confirm that you would like to log out of Medscape. CSF is used in the diagnosis of multiple sclerosis (MS) by identifying increased intrathecal IgG synthesis qualitatively (oligoclonal bands). These tests include the measurement of kappa free light chains in cerebrospinal fluid (CSF) and CSF oligoclonal band (OCB) detection. However, there are other possible causes of elevated OCB levels. According to Mayo Medical Laboratories, this screen is positive in 70 to 80 percent of MS patients. Fortini AS, Sanders EL, Weinshenker BG, Katzmann JA. 2021 Feb 1. The CSF oligoclonal band screen looks for these bands in your CSF. However, most patients with a monoclonal protein will be finally diagnosed with MGUS rather than any of the malignant plasma cell dyscrasias for which treatment is recommended. 135:1048-51. 2011. What specimens can be used to perform an immunofixation test? Exp Ther Med. Haematologica. Isoelectric focusing (IEF) on agarose gels followed by immunoblotting is the technique recommended for OCB detection, analyzing paired undiluted CSF and serum samples. Unable to load your collection due to an error, Unable to load your delegates due to an error. What is the reference range of an immunofixation test? Sample size: Every drop of urine within 24 hours is included in the sample. Before the test, a doctor may order imaging tests, such as a CT scan or an MRI scan, to ensure that it is safe for the person to undergo the procedure. Comparison of the Freelite serum free light chain (SFLC) assay with serum and urine electrophoresis/immunofixation and the N Latex FLC assay. They will clean the skin and numb the area using a local anesthetic. Centrifuge and aliquot serum within 2 hours of collection. The separated immunoglobulins (Ig) are visualized by an IgG immunoblot, and OCBs that are present in the CSF and not in the serum are reported. Role of urine immunofixation in the complete response assessment of MM patients other than light-chain-only disease. Theyll ask you to turn on your side and expose your back. Management of clinically and radiologically isolated syndromes suggestive of multiple sclerosis. Blood Cancer J. Diagnoses in the second group of patients, with unique CSF OCBs in addition to serum OCBs, resembled those among patients with CSF OCBs alone. What causes Oligoclonal banding? A polyclonal immunoglobulin pattern in the serum or urine immunofixation is considered to be nonspecific. When abnormal results are reported back to your physician, further medical investigations can pursue the cause for the increased presence of immunoglobulin proteins in your cerebrospinal fluid. None found; four or more CSF-specific bands have been shown to be most consistent with MS. For Cindy, obsessive compulsive disorder used to dictate most of her life nowadays, shes learned how to forgive, rest, and manage her condition. what conditions show oligoclonal bands in csf and serum? John C Leighton, Jr, MD, FACP is a member of the following medical societies: American College of Physicians, American Medical Association, American Society of Hematology, American Society of Clinical OncologyDisclosure: Nothing to disclose. The Consortium of Multiple Sclerosis Centers has endorsed IEF because of its increased sensitivity (>95%). 22:1262-8. What is Oligoclonal Bands Cerebrospinal Fluid (CSF)andSerum test? This helps your physician identify the reason for any inflammation that may be present in your central nervous system., If there is a presence of oligoclonal bands of protein, multiple sclerosis is sometimes suspected as the cause. Last medically reviewed on March 18, 2022. Technique: Collection starts early in the morning after the first morning urine has been voided and continues for the subsequent 24 hours, including the first morning urine of the following day. On the left a serum protein electrophoresis (SPEP) of a patient with a monoclonal band in the gamma region is shown. StatPearls. The word oligoclonal band comes from the fact that the immunoglobulins appear as separate bands when the CSF is put in a gel plate under the effect of an electric current. Murray DL, Puig N, Kristinsson S, et al. John C Leighton, Jr, MD, FACP Clinical Associate Professor, Jefferson Medical College of Thomas Jefferson University; Chief, Division of Medical Oncology, Jeanes Hospital; Associate Director, Associate Chief, Divisions of Hematology/Medical Oncology, Albert Einstein Cancer Center; Associate Member Kimmel Cancer Center, Thomas Jefferson Hospital myUpchar Ayurveda Urjas Capsule for Vigour & Vitality Support. sharing sensitive information, make sure youre on a federal In some cases, additional time should be Similarly, if a test comes back negative but a person is experiencing symptoms, additional tests may be necessary to confirm what is causing the symptoms. eCollection 2021. Typically, the monoclonal protein is discovered, and workup then ensues. The CSF oligoclonal band screen looks for these bands in your CSF. 2015 May. Geraint Fuller MA MD FRCP, Mark Manford BSc MBBS MD FRCP, in Neurology (Third Edition), 2010. Other reasons your physician may request a CSF oligoclonal banding test are to identify if other serious illnesses are present, such as: A spinal tap can pose a couple of moderate to low risks. Your doctor may suggest you take a mild pain reliever. A positive test might also indicate that you have: As always, give your doctor complete information on what medications you take. Shah D, Seiter K. Multiple myeloma. Abnormal CSF OCB patterns have been reported in 70% to 80% of MS patients. We herein review central and peripheral nervous system conditions associated with OCBs and discuss their relation with pathogenetic mechanisms. Therefore, the International Myeloma Working Group Mass Spectrometry Committee created a set of recommendations for the evaluation of monoclonal proteins in multiple myeloma and related disorders, using mass spectrometry. Can diet help improve depression symptoms? 18008 Bothell Everett Hwy SE # F, Bothell, WA 98012. Among 161 patients in whom both serum and urine demonstrated positive results for monoclonal protein and who were, posttreatment, negative for serum immunofixation, just 3 (1.9%) displayed positive urine immunofixation. The presence of 2 or more unique CSF oligoclonal bands was reintroduced as one of the diagnostic criteria for MS in the 2017 revised McDonald criteria. A doctor may use a CSF oligoclonal banding test to help confirm MS, but they will also need to consider other diagnostic criteria. Oligoclonal immunoglobulin G (IgG) bands (OCBs) are a useful diagnostic tool to detect a central humoral response. The .gov means its official. The diagnosis of multiple sclerosis (MS) is dependent on clinical, radiological, and laboratory findings. PMC Blood. OCBs can also be present in other central nervous system (CNS) disorders, including antibody-mediated, inflammatory, infectious, and neurodegenerative conditions, as well as in both chronic and early disease stages, suggesting the occurrence of primary or concomitant immune-mediated processes. Most useful in diagnosis of multiple sclerosis. They will insert the thin needle between the two bones in the lower back and extract the sample. Serum and CSF Biomarkers Predict Active Early Cognitive Decline Rather Than Established Cognitive Impairment at the Moment of RRMS Diagnosis. sharing sensitive information, make sure youre on a federal Unconcentrated CSF should be compared . He/she will then clean an area on your back with an antiseptic and will inject a local anaesthetic to numb the area. When might mass spectrometry be used in place of immunofixation? 2018 Feb;17(2):162-173, 4. Front Neurol. Please enable it to take advantage of the complete set of features! and transmitted securely. Damage to your spinal cord if you move during the procedure, Cerebral infarction (death of brain tissue due to insufficient blood flow), Idiopathic polyneuritis (inflammation of multiple nerves without an obvious cause), Cryptococcal meningitis (infection in the brain due to Cryptococcus fungus), Subacute sclerosing panencephalitis (a slowly progressive neurological disorder caused by measles virus), Progressive rubella panencephalitis (a neurological condition caused by rubella virus). MS is a disease that affects the CNS, which consists of the brain and spinal cord. An official website of the United States government. A serum sample is taken at the time of the lumbar puncture as oligoclonal bands may be present in CSF alone or CSF and blood. CSF actively serves your body with important functions that include: If your physician suspects inflammation in your central nervous system, they will order a CSF oligoclonal banding. Br J Haematol. [10, 17], A 24-hour concentrated urine sample is appropriate for urine immunofixation. The assay uses reagents from Helena Laboratories. Please enable it to take advantage of the complete set of features! The separated immunoglobulins (Ig) are visualized by an IgG immunoblot, and OCBs that are present in the CSF and not in the serum are reported. Multiple Myeloma. Our website services, content, and products are for informational purposes only. Clinical correlation recommended. 2017 Oct 23;12(10):e0186842. (2014, December 6). Oligoclonal bands are proteins called immunoglobulins. During the procedure, an anesthesiologist will withdraw your spinal fluid by inserting a thin, long needle into your spine above your pelvis. All rights reserved. During the procedure, a person will lie on their side with their legs pulled up toward their chin and their chin tucked in. what conditions show oligoclonal bands in csf and serum?delpark homes sutton what conditions show oligoclonal bands in csf and serum? Amato, A. This gown gives the person conducting the test easy access to your spine. The reason for this is that the presence of OCBs can also indicate other conditions that cause inflammation in the CNS. The complex relationship between oligoclonal bands, lymphocytes in the cerebrospinal fluid, and immunoglobulin G antibodies in multiple sclerosis: Indication of serum contribution. Bands found in both serum and CSF indicate a generalised infection, sarcoidosis (an inflammatory disease affecting many organs), neoplasia or an autoimmune disorder (a condition where the immune system damages normal body tissue). The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). [QxMD MEDLINE Link]. More than 90% of patients with multiple sclerosis show oligoclonal banding at some time during the course of their disease. what conditions show oligoclonal bands in csf and serum? Finally, when several bands with sharp borders are seen after immunofixation in cerebrospinal fluid (CSF) but not in serum, the result is reported as positive for oligoclonal bands. Oligoclonal bands If present in both, they may represent systemic infection, autoimmune disease, sarcoidosis or neoplasia. Accessibility These figures contrast considerably with those reported for patients with CSF OCBs alone. 2015 Aug 26. Centers for Disease Control and Prevention: Systemic Lupus Erythematosus (SLE)., Cerebrospinal Fluid Research: The regulation of brain states by neuroactive substances distributed via the cerebrospinal fluid; a review., Cleveland Clinic: Cerebrospinal Fluid (CSF) Leak., HHS Author Manuscripts: Central Nervous System Agents for Ischemic Stroke: Neuroprotection Mechanisms., JAMA Neurology: Oligoclonal Band Number as a Marker for Prognosis in Multiple Sclerosis., Johns Hopkins Medicine: Neurological Complications of HIV., Mayo Clinic: Multiple sclerosis., Oligoclonal Banding, Serum and Spinal Fluid., Multiple Sclerosis Trust: Lumbar puncture., National Multiple Sclerosis Society: Cerebrospinal Fluid (CSF)., New Medical Life Sciences: What is the Nervous System?, University of California San Francisco Health: Medical Tests CSF oligoclonal banding.. Corrective measures and identification of specialized laboratories with expertise in the field are fundamental to applying this useful technique in clinical practice. Some of the risks for spinal taps include: To minimize the risk of negative reactions, be sure to follow your doctors advice on fluids and foods, and inform them of any allergies to medications., In order to perform the CSF Oligoclonal Banding test, a sample of your cerebrospinal fluid is retrieved. 147:22-42. Clinical correlation recommended. 1. Cerebrospinal fluid oligoclonal bands in the diagnosis of multiple sclerosis. -, N Engl J Med. The presence of more than one band is an indicator of illness. 2009. Increased intrathecal Ig synthesis may occur in other inflammatory CSF diseases and, therefore this assay is not specific for MS. Ask your health query from live doctors now! The procedure usually takes about half an hour. brain herniation if a brain mass is present. [Full Text]. [QxMD MEDLINE Link]. They are used as a marker of MS when magnetic resonance imaging studies of the brain are not diagnostic. The person conducting the test will clean and cover the puncture. CSF is used in the diagnosis of multiple sclerosis (MS) by identifying increased intrathecal IgG synthesis qualitatively (oligoclonal bands). Kaplan JS, Horowitz GL. The above information is provided from a purely educational point of view and is in no way a substitute for medical advice by a qualified doctor. [9]. Am J Clin Pathol. Differentiating patterns of oligoclonal banding in the cerebrospinal fluid improves diagnostic utility for multiple sclerosis. Although an abnormal result supports a diagnosis of multiple sclerosis, it does not confirm the diagnosis. Fortini AS, Sanders EL, Weinshenker BG, Katzmann JA: Cerebrospinal fluid oligoclonal bands in the diagnosis of multiple sclerosis. Clear diagnoses had been made in 112 of these patients: in 56 identical CSF and serum bands were present, revealing a systemic immune response, while in 46 additional unique CSF bands indicated that intrathecal IgG synthesis was also occurring. Dimopoulos M, Kyle R, Fermand JP, et al. The determination of intrathecal IgM, including IgM/lipid-specific IgM OCBs, on the other hand, seems to be of prognostic relevance and is associated with a more aggressive disease course. You should expect to rest for at least an hour after your test. 2021 Laboratory Corporation of America Holdings and Lexi-Comp Inc. All Rights Reserved. Oligoclonal bands can be found in serum in a number of infections (e.g HIV, EBV) and autoimmune diseases. Approach to the patient with neurologic disease. Theyll ask you to hold still, and theyll insert a hollow needle into your lower spine. Collection Instructions: Label specimen as spinal fluid. The results of the CSF oligoclonal banding test can indicate the presence of OCBs or elevated levels of OCB. Oligoclonal bands may be observed in the following conditions: Disclaimer: All results must be clinically correlated with the patients complaints to make a complete and accurate diagnosis. Paired serum and cerebrospinal fluid (CSF) samples were collected for diagnostic purposes after informed consent was obtained. For assistance, contact. Some people have a headache after a lumbar puncture. Clin Chem. In order to confirm local production of oligoclonal IgG in CSF, a matched serum sample is required. [14], Mass spectrometry is sometimes employed in place of immunofixation because of the latters limitations, such as in the detection of low-level disease. In particular, cerebrospinal fluid (CSF)-restricted OCBs represent a hallmark of multiple sclerosis (MS), where they can be detected in > 90% of cases and support its diagnosis, although a specific causative agent inducing B cell activation has not yet been identified. [Full Text]. The presence of 2 or more unique CSF oligoclonal bands was . Call us at (425) 485-6059. Keywords: Oligoclonal bands: An immunological and clinical approach. In addition, when protein electrophoresis assays are positive for a monoclonal protein, serum and urine immunofixation are indicated for the appropriate identification of the immunoglobulin and the corresponding light chain. Some doctors may perform a lumbar puncture using medical imaging for guidance, such as an ultrasound or interventional radiology. This article discusses the link between OCBs and MS and what the testing involves. Subsequent immunofixation with electrophoresis identified the monoclonal protein as an IgG antibody (paraprotein) with a lambda light chain (arrow). Summary Oligoclonal bands (OCBs) are a type of protein that occurs in the cerebrospinal fluid (CSF). They can also use it to diagnose other inflammatory conditions and neurological diseases. [9], Surveillance among patients with MGUS or smoldering (asymptomatic) multiple myeloma, Immunofixation of the urine and serum should be included in a battery of tests after 2-3 months following diagnosis of smoldering myeloma, then every 4-6 months for 1 year, and, finally, every 6-12 months if the results are stable. Note: Normal value ranges may vary slightly among different laboratories. The presence of oligoclonal bands in CSF from patients with multiple sclerosis does not correlate with the activity of the demyelinating process. Saadeh R, Pittock S, Bryant S, et al: CSF kappa free light chains as a potential quantitative alternative to oligoclonal bands in multiple sclerosis. The presence of 2 or more unique CSF oligoclonal bands was reintroduced as one . The presence of no oligoclonal bands or one band is normal. In the first group neoplasia and peripheral neuropathies accounted for over 50% of the diagnoses, infections and systemic inflammatory disorders for 32%, and multiple sclerosis was diagnosed in only one case. Healthline Media does not provide medical advice, diagnosis, or treatment. This site needs JavaScript to work properly. The following article hopes to help you make more suitable . CSF immunofixation that does not reveal oligoclonal bands is also considered normal. Finally, intrathecal humoral immune response can also occur, although rarely, in patients with peripheral neuropathies, particularly in those of inflammatory origin, as a possible consequence of blood-spinal nerve root barrier (BSNRB) damage. The separated immunoglobulins (Ig) are visualized by an IgG immunoblot, and OCBs that are present in the CSF and not in the serum are reported. It sounds that these OGB's may be due to demyelination of brain tissues. and transmitted securely. We avoid using tertiary references. Detection of Oligoclonal Ig Bands: Clinical Significance and Trends in Methodological Improvement. A polyclonal immunoglobulin pattern in the serum . 2019 Jul 15. Detection of oligoclonal bands in cerebrospinal fluid by immunofixation electrophoresis. 1988 Sep;38(9):1391-8 Simonsen CS, Flemmen H, Lauritzen T, Berg-Hansen P, Moen SM, Celius EG. Would you like email updates of new search results? [12] an additional assay for the identification of IgD or IgE must be performed. [Full Text]. [QxMD MEDLINE Link]. Follow-up of multiple myeloma, Waldenstrom macroglobulinemia, and AL amyloidosis, Immunofixation of urine and serum samples should be performed in all patients with multiple myeloma, Waldenstrom macroglobulinemia, and AL amyloidosis every 3 months after the completion of treatment in order to evaluate for response or to document a relapse. Careers. If similar bands arent present in your blood, you may have multiple sclerosis (MS). Acta Neurol Scand. Oligoclonal bands may be observed in the following conditions: Multiple sclerosis Viral and bacterial meningitis HIV (AIDS) Cerebral infarction (death of brain tissue due to insufficient blood flow) Guillain-Barr syndrome (an autoimmune condition that affects the nerves) Neurosyphilis [Full Text]. In this context, recent research has focused on the automated assessment of CSF kappa free light Ig chains as a more sensitive, non-operator-dependent marker of intrathecal Ig synthesis. Side effects may occur from mAbs treatment including rash, diarrhea, nausea, dizziness and pruritis (itchy skin). Once the sample is retrieved, it is analyzed in a medical laboratory., Normal results are reported when no immunoglobulin proteins, called oligoclonal bands, are found in your cerebrospinal fluid.. Laboratory findings, including CSF cell count, CSF protein concentration, the quotient of albumin (Qalb), IgG index, and the percentage with positive oligoclonal IgG bands, and baseline treatment . Oligoclonal Bands . The test requires both CSF and serum samples. MNT is the registered trade mark of Healthline Media. Gurtner KM, Shosha E, Bryant SC, Andreguetto BD, Murray DL, Pittock SJ, Willrich MAV. The site is secure. (Press Enter or Space to Go to Landing Page or Press Down to expand Menu), Federally Qualified Health Centers (FQHCs), Combatting Modern Slavery and Human Trafficking Statement. Learn more here. Your test results should be ready in a couple of days. What do Oligoclonal Bands CSF and Serum test results mean? In this case, further tests will be necessary to determine the cause of any disease. June 11, 2022 Posted by: when was arthur miller born . In addition, serum oligoclonal bands are present in some patients with Hodgkin's disease and in up to 5% of normal individuals. Any medical information published on this website is not intended as a substitute for informed medical advice and you should not take any action before consulting with a healthcare professional. The purpose of this test is to determine whether or not there are immunoglobulin proteins called oligoclonal bands dwelling in your cerebrospinal fluid. Gurtner KM, Shosha E, Bryant SC, et al: CSF free light chain identification of demyelinating disease: comparison with oligoclonal banding and other CSF indexes. Collection Instructions: Label specimen as spinal fluid. The detection of increased intrathecal immunoglobulin synthesis is the basis for current diagnostic laboratory tests for MS. This test is usually ordered if your doctor thinks you may have MS. The presence of these bands implies inflammation in the central nervous system (CNS) which may be caused by an infection or a disease. When the oligoclonal band assay detects 2 or more unique IgG bands in the cerebrospinal fluid (CSF), the result is positive. Collection in a container: A plastic collection container is used. Hereditary spastic paraparesis. Monoclonal antibodies are one such treatment that may . A person does not need to do much to prepare for the test itself. The presence of 2 or more unique CSF oligoclonal bands was reintroduced as one of the diagnostic criteria for MS in the 2017 revised McDonald criteria. Increased intrathecal Ig synthesis may occur in other inflammatory CSF diseases and, therefore this assay is not specific for MS. CSF Oligoclonal Bands Interpretation: <2 bands. government site. The presence of oligoclonal bands (OCBs) of immunoglobulin G (IgG) in CSF provides evidence for the occurrence of a humoral immune response, but it is not always appreciated that the oligoclonal IgG may have originated in the serum. Clipboard, Search History, and several other advanced features are temporarily unavailable. CSF oligoclonal banding is a test ordered by physicians when serious health concerns related to your central nervous system arise. Oligoclonal bands are found in up to 95 percent of patients with clinically definite MS . Clin Chem Lab Med. Ferraro D, Trovati A, Bedin R, Natali P, Franciotta D, Santangelo M, Camera V, Vitetta F, Varani M, Trenti T, Gastaldi M, De Biasi S, Nasi M, Pinti M, Meletti S, Sola P. Eur J Neurol. This test has been cleared, approved, or is exempt by the US Food and Drug Administration and is used per manufacturer's instructions. Autoimmune disorders. However, the presence of oligoclonal bands does not necessarily confirm the diagnosis, as other conditions can present with oligoclonal bands in the CSF. 2022 Oct 23;12(11):2571. doi: 10.3390/diagnostics12112571. Sin categorizar; what conditions show oligoclonal bands in csf and serum? 2021 Sep;41(9):775-784. doi: 10.1007/s40261-021-01071-0. Labs & Appointments Toggle Labs & Appointments, Billing & Insurance Toggle Billing & Insurance, Diseases & Conditions Toggle Diseases & Conditions, OnDemand Testing Toggle OnDemand Testing, Testing by Disease & Condition Toggle Testing by Disease & Condition, Testing & Services For Toggle Testing & Services For, Hospitals & Physician Systems Toggle Hospitals & Physician Systems, Managed Care Health Plans Toggle Managed Care Health Plans, Lab Data Integrations & Tools Toggle Lab Data Integrations & Tools, Employee Wellness & Testing Toggle Employee Wellness & Testing, Government & Education Toggle Government & Education, Therapeutic Indications Toggle Therapeutic Indications, Development Phase Toggle Development Phase, Compounds & Molecules Toggle Compounds & Molecules. The presence of these proteins indicates inflammation of the central nervous system. Twenty-four-hour Bence-Jones protein determinations: can we ensure accuracy?.